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NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss
Aggregates of amyloid-beta (A) and tau are hallmarks of Alzheimer's disease (AD) leading to neurodegeneration and synaptic loss. While increasing evidence suggests that inhibition of N-methyl-D-aspartate receptors (NMDARs) may mitigate certain aspects of AD neuropathology, the precise role of different NMDAR subtypes for A-and tau-mediated toxicity remains to be elucidated. Using mouse organotypic hippocampal slice cultures from arcA transgenic mice combined with Sindbis virus-mediateddoi:10.5167/uzh-89099 fatcat:ewtpipiksbbunil4rqzw2e3ec4