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Situated among the rare bone tumors, the primary di use large B-cell lymphoma occupies a well-worth place in doctor's attention given the di culty of diagnosis and the speci c treatment, as well as the high lay time in showing of the clinical features. Biopsy followed by imunohistochemistry is the gold standard in investigations. e presentation that follows shows a rare case of the primary di use large B-cell lymphoma in the humerus. To the best of our knowlege this is the rst case reported in the Romanian medical literature.doi:10.33311/medcon.2014.31.3.10 fatcat:eryrqcniovgthoxopra4sdigea