Bacteria are a group of microorganisms which in contrast to their diversity in nature, only very few of them can be grown and isolated in the current standard laboratories. Metagenomics as a new field of research, during the last decade has worked on clarification of the genomes of the non-cultured microbes and researchers around the world with serious study of this group of bacteria, looking for new compounds such as new antibiotics, anti-cancer agents, new enzymes and biomolecules. Methods:

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... is article is reviews study which with study of Texts and Internet and handy browsing of key words from reliable scientific resources and sites amongst: Google Scholar, Pub med, Science direct, Sid and Scopus in the years 2000 to 2013 were collected and studied. Results: The data collection instrument in the study includes all printed metagenomics related texts. Although, nowadays metagenomics is used to screen samples but now as a perfect technique beside the medium application and other traditional techniques will have better position. The highest usage of metagenomics is in clinical cases where with conventional techniques can't be discovered microbial reasons. So for tests and analyze information need to skilled scientists. Conclusion: This paper focuses on some of the latest achievements of Metagenomics and its application in new drugs, detection of enzymes, potential of biotechnology and environment.