Clinical effects of miconazole in patients with mycosis associated with various hematological diseases or with pyrexia resistant to antibiotics
各種血液疾患に伴う真菌症および抗生剤に反応しない発熱患者に対するミコナゾールの効果

AKIO URABE, FUMIMARO TAKAKU, HIDEAKI MIZOGUCHI, MICHIHIKO MASUDA, TAKEO NOMURA, SHIN-ICHIRO KURIYA, ATSUSHI TOGAWA, MASAMICHI AMANO, SEITOKU FUJIOKA, TSUNEHIRO SAITO, KINUKO MITANI, HISOMU YAMAGUCHI (+1 others)
1988 Chemotherapy  
Miconazole, an antimycotic agent was administered to 23 patients with mycosis associated with severe hematological diseases or with pyrexia suspected as being mycotic in order to examine its clinical and side-effects. Subjects were 9 cases of pulmonary mycosis or mycotic pneumonia, 1 case of Candida esophagitis and 13 cases of suspected mycotic sepsis. Miconazole was given by drip infusion2 or 3 times a day at a dose of 200 to 400 mg. Clinical results were remarkably effective in 2, effective
more » ... 15, and ineffective in 6 cases, with an efficacy rate of 73. 9%. Side-effects were eruption in 2 and abnormal values of GOT, GPT, T-GTP, Al-P and LDH in 1. The above results suggest that this preparation is effective against visceral mycosis and antibioticresistant pyrexia of unknown cause.
doi:10.11250/chemotherapy1953.36.19 fatcat:7qjb2ncg5bghzou5bpbt4755wi