PARS: a web server for the prediction of Protein Allosteric and Regulatory Sites

Alejandro Panjkovich, Xavier Daura
2014 Computer applications in the biosciences : CABIOS  
The regulation of protein activity is a key aspect of life at the molecular level. Unveiling its details is thus crucial to understanding signalling and metabolic pathways. The most common and powerful mechanism of protein-function regulation is allostery, which has been increasingly calling the attention of medicinal chemists due to its potential for the discovery of novel therapeutics. In this context, PARS is a simple and fast method that queries protein dynamics and structural conservation
more » ... o identify pockets on a protein structure that may exert a regulatory effect on the binding of a small-molecule ligand. Availability: PARS is freely available as a web server at http://bioinf. uab.cat/pars.
doi:10.1093/bioinformatics/btu002 pmid:24413526 fatcat:uswf4otuu5bnjofb2pf3fy4i5q