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Molecular dynamics simulation‐guided toehold mediated strand displacement probe for single‐nucleotide variants detection
2022
Exploration
Single nucleotide variant (SNV) has become an emerging biomarker for various diseases such as cancers and infectious diseases. Toehold-mediated strand displacement (TMSD), the core reaction of DNA nanotechnology, has been widely leveraged to identify SNVs. However, inappropriate choice of mismatch location results in poor discrimination ability. Here, we comprehensively investigate the effect of mismatch location on TMSD kinetics by molecular dynamic simulation tool oxDNA through umbrella
doi:10.1002/exp.20210265
fatcat:b6hdxz6h2zhglopddersh2lqse