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Radical in the Peroxide-Produced F-Type Ferryl Form of Bovine Cytochrome c Oxidase
2022
International Journal of Molecular Sciences
The reduction of O2 in respiratory cytochrome c oxidases (CcO) is associated with the generation of the transmembrane proton gradient by two mechanisms. In one of them, the proton pumping, two different types of the ferryl intermediates of the catalytic heme a3-CuB center P and F forms, participate. Equivalent ferryl states can be also formed by the reaction of the oxidized CcO (O) with H2O2. Interestingly, in acidic solutions a single molecule of H2O2 can generate from the O an additional
doi:10.3390/ijms232012580
fatcat:wfklnvgypfdifgqotkeo4pmitu