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Serum Amyloid A and Lipoprotein Retention in Murine Models of Atherosclerosis
Arteriosclerosis, Thrombosis and Vascular Biology
Objective-Elevated serum amyloid A (SAA) levels are associated with increased cardiovascular risk in humans. Because SAA associates primarily with lipoproteins in plasma and has proteoglycan binding domains, we postulated that SAA might mediate lipoprotein retention on atherosclerotic extracellular matrix. Methods and Results-Immunohistochemistry was performed for SAA, apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), and perlecan on proximal aortic lesions from chow-fed low-densitydoi:10.1161/01.atv.0000158383.65277.2b pmid:15692094 fatcat:w3gqswr5pzalbom2gybst7bzfu