Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness

Peter Fettes, Laura Schulze, Jonathan Downar
2017 Frontiers in Systems Neuroscience  
Frontiers in Systems Neuroscience | www.frontiersin.org FIGURE 1 | Structure of the cortico-striatal loops stemming from the orbitofrontal cortex (OFC) subregions. (A) Schematic showing the entire medial OFC (mOFC) cortico-striatal loop, originating from the mOFC shown in red. (B) Schematic showing the entire lateral OFC (lOFC) cortico-striatal loop, originating from the lOFC shown in blue. mOFC, medial orbitofrontal cortex; VM Caudate, ventromedial caudate; NAcc, nucleus accumbens; GPi, globus
more » ... pallidus interna; SN, substantia nigra; DM Thalamus, dorsomedial thalamic nuclei; VA Thalamus, ventroanterior thalamic nuclei; VL Thalamus, ventrolaterial thalamic nuclei. Frontiers in Systems Neuroscience | www.frontiersin.org
doi:10.3389/fnsys.2017.00025 pmid:28496402 pmcid:PMC5406748 fatcat:nnyxkd6tungtnk2gvpohhbbyeu