Macroprolactinemia: prevalence and clinical characteristics in a cohort of hyperprolactinemic patients assessed for macroprolactinemia

Joanna Prokop, Raquel Espirito Santo, Teresa Sabino, Conceicao Godinho, Ana Agapito
2016 Endocrine Abstracts  
Among premenopausal women with macroPRL the most common complaints were: galactorrhea (23,5%), menstrual irregularities (29,4%), infertility (29,4%), while among those with true hyperPRL they were found in 45%, 50%, and 15% respectively. Some of the patients presented more than one symptom. No symptoms were reported in 22,2% of patients with macroPRL and 14,8% with true hyperPRL. Three male patients had macroPRL and symptoms: erectile dysfunction, infertility or galactorrhea. Two men with true
more » ... Two men with true hyperPRL presented erectile dysfunction with gynecomastia and headaches with visual disturbances (Table 2). Factor Monomeric prolactin N=29 Macroprolactin (N=21) Age* (yr) 42 (21-90) 39 (23-60) Sex, no. (%) Men 2 (7) 3 (14) Women 27 (93) 18 (86) Total prolactin* (ref.range 3,46-19,40 ng/mL) (min.-max.) 76 (28-281) 82 (25-283) Monomeric prolactin* (ng/mL) (min.-max.) 76 (18-297) 10 (2-21) Prolactin recovery* (%) (min.-max.) 97 (63-142) 17 (1-39) Presenting Complaints Monomeric prolactin, Number of patients
doi:10.1530/endoabs.41.ep925 fatcat:d6bo6gbao5h6fjdhke6zekvqku