Internet Archive Scholar

Erythrocyte alloimmunization, rhesus and kell phenotypes for women of childbearing age in Yaounde

Ngo Sack Françoise, Senior Lecturer of Haematology, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon, and Head of Department of Clinical Haematology, Yaoundé Central Hospital, Yaounde, Cameroon, Tchongouang David, Chetcha C Bernard, Essomba René, Higher Institute of Health Professions, Yaoundé, Cameroon and Laboratory Bethany, Yaounde, Cameroon, Senior Lecturer of Haematology, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon, and Clinician in Haematology, Yaoundé Central Hospital, Yaounde, Cameroon, Higher Institute of Health Professions, Yaoundé, Cameroon
2018 The Journal of Medical Research  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (702.4 kB)
https://web.archive.org/web/20190625040952/http://www.medicinearticle.com/JMR_20181_06.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL. The file type is application/pdf.

Erythrocyte alloimmunization has adverse consequences for polytransfused and obstetric for the fetus of an allo immune mother. However, it remains undervalued in our country. To give an estimate, from September to December 2016, we conducted a prospective study that included 157 women, including 54 transfused and 103 women who previously had a history of non-transfusion obstetrics. These patients were recruited from the maternity ward at Central Hospital in Yaounde. Irregular agglutinins (IA)
more » ... re investigated at the Freelys Nano and tube stations using the indirect Coombs technique, blood grouping in the ABO system, and rhesus and Kell phenotypes were made on a plate by the agglutination technique at the Bethany laboratory. Regarding the incidence of irregular agglutinins in nontransfused women with an obstetrical history, 21% (22/103) were positive at RAI. Similarly, 33% (18/54) of the polytransfused multiparas were alloimmune. Similarly, 33% (18/54) of the polytransfused multipares were immunized. The most frequent antigenic combinations in the study population were D+C-E-c+e+ (60%), D+C+E-c+e+ (24%). D+C+ E-c+e+(0.61%), D+C-E+c+ (0.61%), D+C+E+c+e+ (1.8%) were rare. The most found antigens were: c (99%), e (99%), D (97%) and d (2%), K+ (1%) were rare. To reduce the risk of allo immunization in Cameroon phenotype at least in rhesus and Kell systems, the search for irregular agglutinins must be done routinely in transfusion therapy and in obstetrics. Transfusion of non-phenotyped blood should be formally prohibited in the general population; especially among women of reproductive age.
doi:10.31254/jmr.2018.4106 fatcat:zfdnykpiefdpphv6b6rcehywey
Open Access
Citation

Ngo Sack Françoise, Senior Lecturer of Haematology, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon, and Head of Department of Clinical Haematology, Yaoundé Central Hospital, Yaounde, Cameroon, Tchongouang David, Chetcha C Bernard, Essomba René, Higher Institute of Health Professions, Yaoundé, Cameroon and Laboratory Bethany, Yaounde, Cameroon, Senior Lecturer of Haematology, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon, and Clinician in Haematology, Yaoundé Central Hospital, Yaounde, Cameroon, Higher Institute of Health Professions, Yaoundé, Cameroon. "Erythrocyte alloimmunization, rhesus and kell phenotypes for women of childbearing age in Yaounde." The Journal of Medical Research 4.1 (2018) 20-23