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Self-replicating technologies pose a challenge to the legal regimes we ordinarily rely on to promote a balance between innovation and competition. This Article examines recent efforts by the federal courts to deal with the leading edge of this policy challenge in cases involving the quintessential self-replicating technology: the seed. In a recent series of cases involving the invocation of the patent exhaustion defense by purchasers of Monsanto's "Roundup-Ready" genetically engineereddoi:10.2139/ssrn.2184589 fatcat:pyhiryrrwbd23iklj5e5rqzgei