Determining underlying mechanisms during the recovery process after a stroke by means of longitudinal TMS-EEG evaluation

Friedhelm Hummel
2023 Brain Stimulation  
The underlying neuronal mechanisms sustaining motor recovery after stroke are still not completely understood. Changes in inhibitory and excitatory intracortical activity have been suggested as core mechanisms occurring after a stroke. Their supportive or maladaptive roles in the course of recovery are not completely understood; despite this understanding is critically important to better determine outcome, course of the recover and probably response to treatment. Concurrent TMS-EEG will be
more » ... oduced as an exciting method to study brain reactivity, TMS-evoked and induced oscillatory activity by means of single and paired-pulse TMS protocols in a large cohort of stroke patients to better understand recovery processes. Strong support will be provided for the usefulness of TMS-EEG in regard of the mentioned research questions. In more detail, the presented TMS-EEG findings will underline the critical role of dynamic changes of cortical (dis-/)inhibition to foster structural and functional plasticity and reduce impairment and promote long-term motor recovery after a stroke. This presentation will provide evidence for the exciting potential of TMS-EEG to provide markers to determine outcome and to help steer interventional treatment strategies to each patient. Furthermore, challenges and next developments required for clinical translation will be critically discussed.
doi:10.1016/j.brs.2023.01.095 fatcat:phov44ydenaq7lk5vylz4yx7le