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Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure. The human X chromosome is known to have acquired DNA through distinct evolutionary events and is believed to be composed of five evolutionary strata. In addition, in female mammals all copies of X chromosome in excess of one are transcriptionally inactivated. Thedoi:10.1371/journal.pone.0007885 pmid:19946363 pmcid:PMC2776969 fatcat:sfbusegfljfilhomcdjalwmrfm