Objective: To evaluate the anticonvulsant and anxiolytic effect of ethanolic extract of Leaves of Punica granatum Linn. Methods: The anticonvulsant effect of the Ethanolic extract of Punica granatum Linn (EEPG 100 and 200 mg/kg) were evaluated in rat using the Maximal electroshock (MES) and Pentylenetetrazole (PTZ) induced seizure models. Standard drug taken for MES model was Phenytoin 25mg/kg. In PTZ model standard drug taken was diazepam 4mg/kg. Anxiolytic activity was evaluated in mice using

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... the elevated plus maze (EPM) and the mirror chamber methods. Diazepam 2mg/kg was taken as standard anxiolytic drug in both the models. The acute toxicity studies and phytochemical analysis of the extract were also carried out. Results: in MES model Ethanolic extract of Punica granatum Linn (EEPG) completely abolished hind limb extensor phase and decreased the duration of tonic flexor phase. In PTZ model it significantly delayed onset of jerks, number and average duration of convulsion in a dose dependent manner. In EPM number of entry to open arm and average time spent per entry in open arm significantly increased. In mirrored chamber latency decreased but number of entry, total time spent per entry and average time per entry all of these are significantly increased. Conclusion: It is concluded that EEPG possess significant anticonvulsant and anti-anxiety activity.