The management of lomustine overdose in malignant glioma patients

Hans-Georg Wirsching, Isabel Tritschler, Antonella Palla, Christoph Renner, Michael Weller, Ghazaleh Tabatabai
2014
Lomustine is an oral alkylating drug commonly used for brain tumor patients. Recently, the lomustine-containing PCV polychemotherapy regime (procarbazine, CCNU/lomustine, and vincristine) in combination with radiotherapy has become the standard of care for anaplastic oligodendroglioma with 1p/19q codeletion and high-risk low-grade glioma. Here, we review the literature of all reported cases of lomustine overdose, highlight complications by exemplifying a case of inadvertent lomustine overdose,
more » ... omustine overdose, and outline the management of this potential complication of outpatient PCV therapy. Lomustine is an oral alkylating drug commonly used for brain tumor patients. Recently, the lomustine-containing PCV polychemotherapy regime (procarbazine, CCNU/lomustine, and vincristine) in combination with radiotherapy has become the standard of care for anaplastic oligodendroglioma with 1p/19q codeletion and high-risk low-grade glioma. Here, we review the literature of all reported cases of lomustine overdose, highlight complications by exemplifying a case of inadvertent lomustine overdose, and outline the management of this potential complication of outpatient PCV therapy.
doi:10.5167/uzh-166324 fatcat:7i3z6ddav5cx5nahiyfrnv32ja