Progress toward the Synthesis of Pochonin J

Sydney N. Jackson, Rongson Pongdee
2019 International Journal of Organic Chemistry  
The construction of the C(1) -C(5) fragment of the resorcylic acid lactone pochonin J is described. The synthesis is marked by the installation of the cis-1,3-diol moiety in a highly stereoselective manner using Evans' intramolecular base-catalyzed oxyconjugate addition of a hemiacetal-derived nucleophile. The synthetic route presented affords an efficient pathway to the preparation of this critical architectural feature that should facilitate the development of this secondary metabolite as a
more » ... y metabolite as a potential drug candidate.
doi:10.4236/ijoc.2019.92009 fatcat:tmmmduakdja3vb6364dsiiujxu