The first report of isolation of macrolide-resistant Bordetella pertussis in Japan

Takahiro Yamaguchi, Yasuhiro Kawasaki, Chihiro Katsukawa, Ryuji Kawahara, Kentaro Kawatsu
2020 Japanese journal of infectious diseases (Print)  
We report the first detection of a macrolide-resistant Bordetella pertussis strain in Japan. The isolate was highly resistant to the macrolides (minimum inhibitory concentrations for erythromycin and clarithromycin: > 256 µg/ml, for azithromycin: 32 µg/ml) and A2047G mutation was identified in the 23S rRNA. The Multilocus Sequence Typing and Multilocus Variable Number of Tandem Repeat Analysis genotypes of this isolate were MT195 and ptxP1/ptxA1/prn1/fim3A/fhaB3, respectively, suggesting a
more » ... , suggesting a relationship with the macrolide-resistant B. pertussis lineage currently found in China. This raises the possibility that macrolide-resistant B. pertussis has already fully spread in Japan. For a better control of B. pertussis infections, the surveillance for macrolide-resistant B. pertussis is essential in not only Japan, but also other Asian countries.
doi:10.7883/yoken.jjid.2019.421 pmid:32350216 fatcat:bcl726rq2zhptgpojskj7tpvyq