A Deferasirox Derivative That Acts as a Multifaceted Platform for the Detection and Quantification of Fe3+

Axel Steinbrueck, Adam C. Sedgwick, Suh-Mi Hwang, Sajal Sen, Michael Y. Zhao, Dan-Ying Huang, Daniel M. Knoll, Yu-Ying Wang, Jonathan L. Sessler
2021 Chemosensors  
Here, we report that ExSO3H, a synthetically accessible, water-soluble, non-toxic derivative of the clinical iron chelator deferasirox, acts as a colorimetric chemosensor that permits the detection and quantification of Fe3+ in aqueous samples at pH 2–5. In addition, we observed that a fluorescent turn-on response was produced when this chelator was allowed to interact with human serum albumin (HSA). This fluorescence was quenched in the presence of Fe3+, thus allowing us to monitor the
more » ... of this biologically important metal cation via two independent methods.
doi:10.3390/chemosensors9040068 doaj:70c03152a38e43829d4ea61007b259b5 fatcat:5ebzgr6rufd4hfrtsfzilirfca