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Journal of Nutrition
The process of chemical carcinogenesis is a complex multistage process initiated by DNA damage in growth control genes. Carcinogens enter the body from a variety of sources, but most require metabolic activation before they can damage DNA. There are multiple protective processes that include detoxification and conjugation, DNA repair and programmed cell death. Most of these functions exhibit wide interindividual variation in the population and thus are thought to affect cancer risk. The role ofdoi:10.1093/jn/129.2.552s pmid:10064330 fatcat:zisu47dnnzboti6hxx5stjprje