Relationship of Octanoylcarnitine Concentrations to Age at Sampling in Unaffected Newborns Screened for Medium-Chain Acyl-CoA Dehydrogenase Deficiency

J. M. Khalid, J. Oerton, G. Besley, N. Dalton, M. Downing, A. Green, M. Henderson, S. Krywawych, V. Wiley, B. Wilcken, C. Dezateux
2010 Clinical Chemistry  
on behalf of the UK Collaborative Study of Newborn Screening for MCADD BACKGROUND: Although octanoylcarnitine (C8) concentrations measured from newborn screening dried blood spots are used to identify those at high risk of medium-chain acyl-CoA dehydrogenase deficiency (MCADD), age-related reference values are currently not available for unaffected newborn populations. Because age at sampling may vary within and between screening programs, variations in C8 concentrations by age may affect
more » ... ing program performance. We determined whether C8 concentrations vary by age at sampling, sex, birth weight, or gestational age in unaffected newborns.
doi:10.1373/clinchem.2010.143891 pmid:20413428 fatcat:pv6fqsbl7jgtbnetmgarggkcj4