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Infant leukaemia – faithful models, cell of origin and the niche
2021
Disease Models & Mechanisms
For patients and their families, the diagnosis of infant leukaemia is devastating. This disease has not seen the improvements in outcomes experienced with other paediatric leukaemias and it is becoming ever more apparent that infant leukaemia is a distinct biological entity. Insights into some of the distinguishing features of infant leukaemia, such as a single mutation – the MLL-gene rearrangement, the biology of disease aggressiveness and lineage plasticity, and the high incidence of central
doi:10.1242/dmm.049189
pmid:34713888
pmcid:PMC8560498
fatcat:odabcemjezehhm3lnaio37yenm