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A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy
2007
Nephrology, Dialysis and Transplantation
Despite the importance of endothelial injury and healing for primary and secondary renal disease and the availability of genetically engineered mouse models, to date no generally applicable murine disease model with site-specific renal endothelial injury has been established. We induced specific microvascular renal injury via selective renal arterial perfusion of the lectin concanavalin A (Con A) followed by sheep anti-concanavalin A and harvested tissues after 4 h, 24 h, days 3 and 7. Compared
doi:10.1093/ndt/gfm774
pmid:18045820
fatcat:2owg4llihfgrngxduglg52i4z4