A 60-day long aquarium trial have been conducted in laboratory condition to evaluate the growth performance of tilapia Oreochromis niloticus fed with different types of synbiotics. Twenty-five homogenous fry were randomly assigned into four different treatments with three replications. Fish were fed with experimental diets containing 0.3% probiotic (PBO)+1.5% molasses, 0.3% PBO+1.5% yeast and 0.3% PBO+1.5% sugar and marked as T1 T4 (control), T2, T3 and T4 and fish in control were feed with

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... ercial diet. Length and weight were recorded in every 10 days and at the end of trial blood sample were collected for hematological analysis. The showed the significantly highest growth performance among treatments and the differences between T1 and T2 found as nonsignificant (P0.05). Hematological analysis showed significant changes among the treatments for hemoglobin, Red Blood Cell (RBC) count and White Blood Cell (WBC) count (P>0.05). All treatments showed a better growth performance in compared to the control group. Finally, present results revealed that synbiotics might modulate the growth performances, hematological indices, and health condition in O. niloticus.