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Pan-cancer studies are particularly relevant not only for addressing the complexity of the inherently observed heterogeneity but also for identifying clinically relevant features that may be common to the cancer types. Immune system regulations usually reveal synergistic modulation with other cancer mechanisms and in combination provide insights on possible advances in cancer immunotherapies. Network inference is a powerful approach to decipher pan-cancer systems dynamics. The methodologydoi:10.4137/cin.s31809 pmid:27147816 pmcid:PMC4849425 fatcat:yq4ax5ga4jfk5ju3ycyphyuutu