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Telomere and Its Role in Diseases
2019
Oncomedicine
Telomeres are highly conservative repeated nucleotide sequences at the ends of linear chromosomes. Allowing effective DNA replication to keep the integrity of gene structure and the stability of chromosomes, telomeres protect the ends of the chromosome from deterioration or from fusion with neighboring chromosomes. Reduction in the telomere length leads to the cessation of cell division and thus cellular senescence. On the other hand, telomerase is a ribonucleoprotein complex with reverse
doi:10.7150/oncm.28210
fatcat:yhvalkxvg5ecdh2y6u2gjw3vta