ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis

S Stein, C Lohmann, C Handschin, E Stenfeldt, J Borén, T F Lüscher, C M Matter
BACKGROUND: Atherosclerosis is a chronic inflammatory disease that evolves from the interaction of activated endothelial cells, macrophages, lymphocytes and modified lipoproteins (LDLs). In the last years many molecules with crucial metabolic functions have been shown to prevent important steps in the progression of atherogenesis, including peroxisome proliferator activated receptors (PPARs) and the class III histone deacetylase (HDAC) SIRT1. The PPAR coactivator 1 alpha (Ppargc1a or PGC-1) was
more » ... identified as an important transcriptional cofactor of PPAR and is activated by SIRT1. The aim of this study was to analyze total PGC-1 deficiency in an atherosclerotic mouse model. METHOD-OLOGY/PRINCIPAL FINDINGS: To investigate if total PGC-
doi:10.5167/uzh-38588 fatcat:smb7oaoovfehbch2wuzcnvjl4i