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One of the central problems in modern biology is to identify the complete set of interactions among the proteins in a cell. The structural interaction of proteins and their domains in networks is one of the most basic molecular mechanisms for biological cells. Structural evidence indicates that, interacting pairs of close homologs usually interact in the same way. In this article, we make use of both homology and inter-domain linker region knowledge to predict interaction between protein pairsdblp:journals/engl/Zaki08 fatcat:6tonc5fu25anjf6suhbszbwqpm