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In this work, we compare two methods for evaluating and quantifying pulmonary airspace enlargement in a mouse model of chronic cigarette smoke exposure. Standard stereological sample preparation, sectioning, and imaging of mouse lung tissues were performed for semi-automated acquisition of mean linear intercept (L m ) data. After completion of the L m measurements, D 2 , a metric of airspace enlargement, was measured in a blinded manner on the same lung images using a fully automated techniquedoi:10.1371/journal.pone.0006670 pmid:19688093 pmcid:PMC2722737 fatcat:tfjicfbljvdqpfagmxvyig5gdy