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Faculty of 1000 evaluation for L1 retrotransposition in human neural progenitor cells
[dataset]
2010
F1000 - Post-publication peer review of the biomedical literature
unpublished
Long Interspersed Element-1 (LINE-1 or L1) retrotransposons have dramatically impacted the human genome. L1s must retrotranspose in the germ-line or during early development to ensure their evolutionary success; yet the extent to which this process impacts somatic cells is poorly understood. We previously demonstrated that engineered human L1s can retrotranspose in adult rat hippocampus progenitor cells (NPCs) in vitro and in the mouse brain in vivo 1 . Here, we demonstrate that NPCs isolated
doi:10.3410/f.1163828.1706079
fatcat:a6mkimur2rb2vijhe34cokw5eq