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Suppression of osteoclastogenesis via upregulation of Zfyve21 and Ddit4 by salubrinal and guanabenz
2016
ORAL THERAPEUTICS AND PHARMACOLOGY
Salubrinal and guanabenz are two known inhibitors of dephosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α), and they suppress osteoclastogenesis through downregulating nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), a master molecule of osteoclastogenesis. The mechanism of NFATc1 suppression is not well understood. Using genome-wide microarray analysis, we investigated molecular regulators of osteoclastogenesis, in particular, in response to salubrinal and
doi:10.11263/jsotp.16.16
fatcat:qxdudfhdorfutiz4ug5nm43iiu