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Analysis of the Effects of Five Factors Relevant to In Vitro Chondrogenesis of Human Mesenchymal Stem Cells Using Factorial Design and High Throughput mRNA-Profiling
2014
PLoS ONE
The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture medium. In general, this leads to a phenotype lacking some of the cardinal features of native articular chondrocytes and their extracellular matrix. The factors used vary, but regularly include members of the transforming growth factor b superfamily and dexamethasone, sometimes
doi:10.1371/journal.pone.0096615
pmid:24816923
pmcid:PMC4015996
fatcat:hxbgvt26hzf5biy4xgoy54zhh4