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Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
1995
Genes & Development
Using homologous recombination, mice lacking cyclin Dl were generated by replacing most of the first exon of the Cyl-1 gene with sequences encoding neomycin resistance. Cyl-1~'~ mice were viable and fertile but consistently smaller than their heterozygous or wild-type littermates. The nullizygous animals also showed two distinctive abnormalities: a severe retinopathy caused by impaired development of all layers of the retina and, in the mammary gland during pregnancy, a marked reduction in
doi:10.1101/gad.9.19.2364
pmid:7557388
fatcat:ba2gn53bbzbivj55wq463w37py