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The twisting direction of nAChR α7-ivermectin is opposite to that of the activated state
The alpha 7 nicotinic acetylcholine receptor (nAChR α7) is composed of five α7 subunits arranged symmetrically around a central pore. nAChR α7 is localized in the central nervous system and immune cells and could be a target for treating Alzheimer's disease and schizophrenia. Acetylcholine (ACh) is a ligand that opens the channel, although prolonged application results in a decrease in the response. Ivermectin (IVM) was reported as one of the positive allosteric modulators, since the binding ofdoi:10.21203/rs.3.rs-2160678/v1 fatcat:yk66hfg7ubdozpabwfjarvtedq