AIM:To study potential mechanism and effects of resveratrol on the proliferation of human retinal vascular endothelial cells in high glucose environment.METHODS:Human retinal vascular endothelial cells were cultured in low glucoseor high glucose environment.The MTT assay was used to detect the proliferation of each group to study the effects of resveratrol on the proliferation of human retinal vascular endothelial cells in high glucose environment. Detection of Sirtuin 1(SIRT1)expression and

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... tylated high mobility group box-1 protein 1(HMGB1)was performed by western-blot and coimmunoprecipitation.RESULTS:Resveratrol inhibited the proliferation of human retinal vascular endothelial cells in high glucose in a dose-dependent manner.High glucose decreased SIRT1 expression andincrease the degree of HMGB1 deacetylation, which can be reversed by resveratrol.CONCLUSION:Resveratrol may reverse proliferation of retinal vascular endothelial cells in high glucose through SIRT1-HMGB1 pathway.