ATRIAL FIBRILLATION AND CHANGE OF EXTRACELLULAR MATRIX
Goriachiy A. V., Gozhenko A. I., Levchenko E. M., Goriachaya A. V. ATRIAL FIBRILLATION AND CHANGE OF EXTRACELLULAR MATRIX. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2019;1(55):101-108. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.2611204 http://aptm.org.ua УДК 616.127-074: 577.12 ± 616.12-008.64-036.1 ± 616.12-008.313: 615.849 ATRIAL FIBRILLATION AND CHANGE OF EXTRACELLULAR MATRIX Goriachiy A.V., Gozhenko A.I., Levchenko E.M., Goriachaya A.V.
... oriachaya A.V. Ukrainian Research Institute of Transport Medicine, Odessa Regional Clinical Hospital Summary The objective: to investigate the changes of serum markers of collagen in patients with various forms of atrial fibrillation (AF). Methods: C-terminal propeptide of type I collagen (CTTP-I), C-terminal telopeptide of type I collagen (CTTC-I), matrix metalloproteinase-I, and tissue inhibitors of matrix metalloproteinase I were used as markers of collagen synthesis. The study group included 70 persons, the control one — 20. Results: The levels of CTPC-I and CTTK-I in patients with AF were significantly higher compared with the control group (91 ± 27 ng / ml., 67 ± 11 ng / ml, p < 0.001 and 0.38 ± 0.20 ng / ml, 0.25 ± 0.08 ng / ml, p < 0.001, respectively). The level of CTPA-I in patients with persistent and chronic forms of AF was significantly higher (105 ± 28 ng / ml and 126 ± 26 ng / ml versus 80 ± 21 ng / ml, p < 0.001) compared with paroxysmal AF patients. Patients with persistent and chronic forms of AF showed significantly lower level of matrix metalloproteinase-1 (MMP-1), however, the level of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) was increased in comparison with patients with paroxysmal AF (09.67 ± 4.41 ng / ml, 11.90 ± 4.79 ng / ml against 14.98 ± 6.28 ng / ml, p = 0.03 and 187 ± 49 ng / ml, 155 ± 45 ng / ml against 130 ± 38 ng / ml, p < 0.001, respectively). The level of TIMMP-1 was significantly lower in the control group compared with patients with paroxysmal, persis [...]