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Mot1 Regulates the DNA Binding Activity of Free TATA-binding Protein in an ATP-dependent Manner
2003
Journal of Biological Chemistry
Mot1 is an essential Snf2/Swi2-related Saccharomyces cerevisiae protein that binds the TATA-binding protein (TBP) and removes TBP from DNA using ATP hydrolysis. Mot1 functions in vivo both as a repressor and as an activator of transcription. Mot1 catalysis of TBP⅐DNA disruption is consistent with its function as a repressor, but the Mot1 mechanism of activation is unknown. To better understand the physiologic role of Mot1 and its enzymatic mechanism, MOT1 mutants were generated and tested for
doi:10.1074/jbc.m211445200
pmid:12571241
fatcat:6kposox77vg6pgvjmouhuvcuui