Systemic Calciphylaxis: Diffuse Cu-taneous Involvement and Ischemic Optic Neuropathy-a case report

Nurshazwani Salleh, Yin Liew
unpublished
Calciphylaxis, or calcific uraemic arteriolopathy, is a rare disease that is difficult and challenging to treat and has a high mortality rate. Its pathogenesis remains to be fully elucidated. Cutaneous manifestations usually predominate although systemic calciphylaxis has been reported, whereby calcifications occur in other organs, including brain, eyes, lungs, intestines and the mesentery. Treatment option is limited. The most common disease-modifying treatment used is intravenous sodium
more » ... venous sodium thiosulphate. We report a case of systemic calciphylaxis in a dialysis-dependent patient who presented with cutaneous lesions and later developed bilateral ischemic optic atrophy. Our case had a poor clinical outcome despite optimal supportive care with multidisciplinary approach and four weeks of intravenous sodium thiosulphate treatment.
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