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The paper describes the use of NMR chemical shift of -SO 2 NH 2 (δ (-SO 2 NH 2 )) moiety as a molecular descriptor for estimating carbonic anhydrase inhibition of CAI (log K i (hCAI)) for a set of sulfonamide incorporating picolinoyl moieties. The results have shown that logK i (hCAI) can be decently estimated in multi-parametric regression analysis consisting of δ (-SO 2 NH 2 ), and the indicator parameters I 1 and I 2 as the correlating parameters. The former indicator parameter is related todoi:10.3998/ark.5550190.0007.g01 fatcat:ref7cobry5hflgxuctvqwnbhmi