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A simple, sensitive, rapid, robust and reproducible method for the determination of Quetiapine Hemi Fumarate (QHF) in bulk and Pharmaceutical Formulation (Tablets) was developed using Reverse Phase High Performance Liquid Chromatographic method (RP-HPLC). The RP-HPLC analysis was performed isocratically on XTERRA C18 (4.6 X 150 mm), analytical column using a mobile phase consisting of Acetonitrile and methanol in the ratio of 60 : 40 v / v, with a flow rate of 1 ml / min. The analyte wasdoi:10.7897/2230-8407.04841 fatcat:aoqtscqcf5bq7dft4hbc4a5v7m