The DRD4 VNTR polymorphism influences reactivity to smoking cues

Kent E. Hutchison, Heather LaChance, Raymond Niaura, Angela Bryan, Andrew Smolen
2002 Journal of Abnormal Psychology  
Recent research has indicated that craving for tobacco can be reliably elicited by exposure to smoking cues, suggesting that cue-elicited craving for tobacco may be a useful phenotype for research on genetic factors related to nicotine dependence. Given the potential role of dopamine in cue-elicited craving, the authors examined whether the DRD4 VNTR polymorphism is associated with cue-elicited craving for tobacco. Participants who were homozygous or heterozygous for the 7 repeat (or longer)
more » ... ele were classified as DRD4 L, and all other participants were classified as DRD4 S. Participants were exposed to smoking cues before smoking either high-nicotine cigarettes or control cigarettes. Analyses suggested that participants in the L group demonstrated significantly greater craving, more arousal, less positive affect, and more attention to the smoking cues than did the participants in the S group.
doi:10.1037/0021-843x.111.1.134 fatcat:dmwnbqknmrgerhsr4nfhimnwmm