Polymerase Chain Reaction in the Management of Patients with Anterior Ophthalmoherpes: a Comparative Study of the Effectiveness of Clinical Use

G. M. Chernakova
2022 Oftalʹmologiâ  
Patiens and methods. We observed 111 patients with various forms of prolonged herpetic keratitis and inflammatory ENT pathology. All patients underwent a study of biological secretions (tear, saliva, blood and urine) for the presence of DNA of herpetic viruses by PCR, systemic antiviral therapy was prescribed. All patients underwent a standard otolaryngological examination, СТ scan of the paranasal sinuses (if necessary), microbiological study of nasopharynx swabs. Local therapy of herpetic
more » ... titis included anti-inflammatory and antibacterial components.Results and discussion. Isolated sinus infalanmmation occurred in 59 % of cases (65 patients), in 38 % of cases (42 patients) there were variants of combinations of sinus inflammation (sinusitis, sphenoethmoiditis, pansinusitis). In 24 % of those included in the study (n = 27), during examination, in addition to the presence or absence of sinusitis, chronic tonsillitis was determined. In 30 % of cases (more often than in other secrets), herpetic viruses were detected in saliva, coccal flora dominated in swabs from the nasopharynx. A marked reduction in ophthalmological symptoms correlated with start of ENT therapy.Conclusions. This clinical and laboratory study showed a close pathogenetic relationship of anterior ophthalmic herpes and concomitant inflammatory pathology of the paranasal sinuses and oropharynx. Active etiotropic therapy of sinusitis and tonsillitis promotes short-term reduction of ophthalmic symptoms.
doi:10.18008/1816-5095-2022-3-630-637 fatcat:oxgm5dkr7bhg7eszp6h256vqlq