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Soluble immune complexes (IC) can be detected in the serum of diabetic patients in frequencies ranging from 25 to 46%, depending on the screening technique used. Insulin-treated diabetics show a high frequency of insulin- anti-insulin IC (61% vs 4% in non-insulin treated patients) while other non-specific screening techniques show similar positivity frequencies in these two populations of diabetics. Soluble IC were isolated from the sera of 6 patients (5 under insulin treatment) using severaldoi:10.1055/s-0038-1652120 fatcat:3hqjula3mzc2relkqgdg3jiige