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Parkinson's disease (PD) is a neurodegenerative disorder that affects 1% of the population over the age of 60. Diabetes Mellitus (DM) is a metabolic disorder that affects approximately 25% of adults over the age of 60. Recent studies showed that DM increases the risk of developing PD. The link between DM and PD has been discussed in the literature in relation to different mechanisms including mitochondrial dysfunction, oxidative stress, and protein aggregation. In this paper, we review thedoi:10.3390/ijms22062953 pmid:33799467 pmcid:PMC8001823 fatcat:zyvsdytrkjhwtcbdbnceizscny