2-Deoxyribose Gene-Enzyme Complex in Salmonella typhimurium: Regulation of Phosphodeoxyribomutase

Patricia A. Hoffee, B. C. Robertson
1969 Journal of Bacteriology  
Phosphodeoxyribomutase, the enzyme which catalyzes the interconversion of 2deoxyribose-l-phosphate to 2-deoxyribose-5-phosphate, has been partially purified from Salmonella typhimurium. The enzyme had an absolute requirement for manganese ion and was stimulated by glucose-1,6-diphosphate. Phosphodeoxyribomutase was induced by deoxyribose-5-phosphate and was coordinately regulated with the enzymes thymidine phosphorylase and deoxyribose-5-phosphate aldolase, type II. Mutants deficient in these
more » ... eficient in these three enzymes were isolated and mapped close to the threonine locus in S. typhimurium. The three enzymes thymidine phosphorylase, deoxyribose-5-phosphate aldolase, type II, and phosphodeoxyribomutase are controlled by a series of linked genes and appear to constitute an operon. on May 9, 2020 by guest
doi:10.1128/jb.97.3.1386-1396.1969 fatcat:kiylevjyd5a77cbpeq5hg3i4xy