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Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data
2019
Molecular Systems Biology
Endothelins (EDN) are peptide hormones that activate a GPCR signalling system and contribute to several diseases, including hypertension and cancer. Current knowledge about EDN signalling is fragmentary, and no systems level understanding is available. We investigated phosphoproteomic changes caused by endothelin B receptor (ENDRB) activation in the melanoma cell lines UACC257 and A2058 and built an integrated model of EDNRB signalling from the phosphoproteomics data. More than 5,000 unique
doi:10.15252/msb.20198828
pmid:31464372
pmcid:PMC6683863
fatcat:dcszrdqhnndgvknbdkx7kavc6y