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Autoregulatory control of microtubule binding in the oncogene, doublecortin-like kinase 1
The microtubule-associated protein (MAP), doublecortin-like kinase 1 (DCLK1), is highly expressed in a range of cancers and is a prominent therapeutic target for the development of kinase inhibitors. However, the physiological roles of its kinase activity and how DCLK1 kinase activity is regulated remain elusive. Here we employ in vitro reconstitution with purified proteins to analyze the role of DCLK1 kinase activity in regulating microtubule binding. We find that DCLK1 autophosphorylates adoi:10.1101/2020.06.12.149252 fatcat:xegnoox6nrgqpfj3ytlnm2wqra