SUMMARY: Gastrointestinal Stromal Tumor: experience of a single center
L Lupo, M Tedeschi, P Panzera, S Roselli, M De Fazio, A Marzullo, D Piscitelli, A Gentile, V Memeo
Gastrointestinal stromal tumor (GIST) is the most frequent mesenchymal neoplasm of the gastrointestinal tract. GIST occur most frequently in the stomach (60%), jejunum and ileum (30%), and less frequently in the deuodenum (5%), colon and rectum,esopha-gus and appendix. Nowadays GISTs are classified according to Fletch-er's classification. Objective: To rewiew the features of our GIST population and to analyse the outcomes of the patient treated at a single institution and followed-up
... ly. Patients and methods: Between August 1997 and March 2009 33 patients with GIST were treated at our institute. Patients were followed up with medical visit and blood sample tests every six mounth and with CT scan every 1 year. Data were analized with parametric and non-parametric tests. Results: Gender distribution of patient was 16 male (49%) and 17 female (51%); mean age of patient was 62 (37-83). Tumor location was as follow: stomach 18 (56%), ileum 6 (18%), colon-rectum 3 (9%), esophagus 2 (6%), duodenum 1 (3%), jejune 1(3%), mesen-tere 1 (3%) e lesser omentum 1 (3%). Tumors were classified according to Fletcher's criteria as high risk (4=12.5%), intermediate risk (10=31%), low risk (18=56%) 30 patients underwent to R0 resection (94%) while 2 of them R1 resection (6%). No patients were treated with Imatinib after surgical treatment. Metastasis or tumor relapse occurred in two patient. Bigger lesions were statistically located in lower gastrointestinal tract (ANOVA p=0.045, Mann Whitney p=0.043). A strong correlation was found between the size of the lesion and the grading of the tumor (ANOVA p=0.0001). So far upper GISTs seam to be correlated to a lower grading (Mann Whitney p=0.043) The survival rate was 90% with a median follow-up of 46 months. Death occurred in 1 patients but the death was not correlated to disease. Conclusion: Our results are in according with the literatute in wich there is no different in sex distribution and the majority of cases are gastric tumors. The survival rate was 90% with a median follow-up of 46 months. Bigger lesions were statistically located in lower gas-trointestinal tract and upper GISTs seam to be correlated to a lower grading.