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Design of pharmaceutical tablet formulation for a low water soluble drug, search for the critical concentration of starch based disintegrant applying percolation theory and F-CAD (Formulation-Computer Aided Design)
2012
unpublished
Preserved Fulltext
to the percolation threshold of sensitive tablet properties such as the disintegration time to get information about the robustness of the selected formulation. In this context one has to put the question forward if the application of percolation theory should be an integral part of the guidelines of ICH Q8 exploring the formulation design space.
doi:10.5451/unibas-005941838
fatcat:cyu2sqy4zjgbxfj6wjk6q2p35a