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Method development and validation of LC and Densitometric-TLC for simultaneous estimation of rosuvastatin calcium and ezetimibe in combined dosage forms
Scholars Research Library Der Pharma Chemica
Two simple and accurate methods to determine rosuvastatin calcium (ROS) and ezetimibe (EZE), in combined dosage form, were developed and validated using liquid chromatography (LC) and densitometric-thin layer chromatography (TLC). The LC separation was achieved on a Phenomenex Luna C 18 column (250 mm, 4.6mm i.d., 5µm), in the isocratic mode using 0.65 M ammonium acetate buffer: methanol: acetonitrile: (30: 40: 30, v/v/v), pH 7.2 ± 0.05 at a flow rate of 1 mL/min. The retention times were aboutfatcat:t7ilgvvldnblbltoopyme6x7py